Giuseppe Pignataro Selected Research

Sodium-Calcium Exchanger

1/2020	Sumoylation of sodium/calcium exchanger in brain ischemia and ischemic preconditioning.
1/2018	Acute and long-term NCX activation reduces brain injury and restores behavioral functions in mice subjected to neonatal brain ischemia.
3/2016	NCX1 Exchanger Cooperates with Calretinin to Confer Preconditioning-Induced Tolerance Against Cerebral Ischemia in the Striatum.
8/2015	Pharmacological characterization of the newly synthesized 5-amino-N-butyl-2-(4-ethoxyphenoxy)-benzamide hydrochloride (BED) as a potent NCX3 inhibitor that worsens anoxic injury in cortical neurons, organotypic hippocampal cultures, and ischemic brain.
5/2015	Sp3/REST/HDAC1/HDAC2 Complex Represses and Sp1/HIF-1/p300 Complex Activates ncx1 Gene Transcription, in Brain Ischemia and in Ischemic Brain Preconditioning, by Epigenetic Mechanism.
2/2013	NCX1 is a new rest target gene: role in cerebral ischemia.
1/2013	Genetically modified mice as a strategy to unravel the role played by the Na(+)/Ca (2+) exchanger in brain ischemia and in spatial learning and memory deficits.
1/2013	Transcriptional regulation of ncx1 gene in the brain.
1/2012	NCX1 and NCX3: two new effectors of delayed preconditioning in brain ischemia.
1/2011	The NCX3 isoform of the Na+/Ca2+ exchanger contributes to neuroprotection elicited by ischemic postconditioning.

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Giuseppe Pignataro Research Topics

Disease

25	Stroke (Strokes) 06/2022 - 12/2007
24	Brain Ischemia (Cerebral Ischemia) 06/2022 - 11/2004
16	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 11/2021 - 04/2006
12	Ischemia 06/2022 - 11/2004
9	Infarction (Infarctions) 06/2022 - 03/2004
9	Hypoxia (Hypoxemia) 01/2021 - 12/2005
5	Brain Injuries (Brain Injury) 01/2018 - 12/2005
3	Ischemic Stroke 01/2021 - 01/2013
2	Neurologic Manifestations (Neurological Manifestations) 01/2022 - 12/2007
2	Brain Infarction 01/2021 - 03/2004
2	Central Nervous System Diseases (CNS Diseases) 01/2021 - 10/2016
2	Alzheimer Disease (Alzheimer's Disease) 01/2020 - 08/2011
2	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2020 - 08/2011
2	Nervous System Diseases (Neurological Disorders) 01/2020 - 04/2003
2	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2018 - 02/2008
2	Pathologic Processes 01/2011 - 02/2008
2	Acidosis 02/2008 - 01/2007
1	Neuroinflammatory Diseases 01/2022
1	COVID-19 01/2022
1	Hemorrhagic Stroke 01/2021
1	Fetal Hypoxia 01/2021
1	Fetal Growth Retardation (Intrauterine Growth Retardation) 01/2021
1	Hemorrhage 01/2021
1	Pregnancy Complications 01/2021
1	Multiple Sclerosis 01/2020
1	Spinal Muscular Atrophy (Progressive Muscular Atrophy) 01/2020
1	Gliosis 12/2018
1	Neoplasms (Cancer) 01/2017
1	Neoplasm Metastasis (Metastasis) 01/2017
1	Brain Edema (Cerebral Edema) 09/2015
1	Mitochondrial Diseases (Mitochondrial Disease) 02/2014

Drug/Important Bio-Agent (IBA)

12	Sodium-Calcium ExchangerIBA 01/2020 - 11/2004
10	Protein Isoforms (Isoforms)IBA 06/2022 - 04/2006
8	CalciumIBA 06/2022 - 04/2006
8	Proteins (Proteins, Gene)FDA Link 04/2016 - 11/2004
7	Neuroprotective AgentsIBA 06/2022 - 05/2007
6	SodiumIBA 06/2022 - 04/2006
6	Glucose (Dextrose)FDA LinkGeneric 11/2021 - 03/2011
6	Oxygen (Dioxygen)IBA 11/2021 - 03/2011
5	MicroRNAs (MicroRNA)IBA 01/2021 - 10/2014
5	IonsIBA 01/2021 - 04/2006
4	Histone Deacetylases (Histone Deacetylase)IBA 10/2020 - 01/2013
3	AntiportersIBA 06/2022 - 01/2013
3	Ion Channels (Ion Channel)IBA 01/2021 - 01/2018
3	Histones (Histone)IBA 10/2020 - 01/2013
3	sodium-calcium exchanger 1IBA 10/2014 - 03/2011
3	Reactive Oxygen Species (Oxygen Radicals)IBA 02/2014 - 04/2003
3	Messenger RNA (mRNA)IBA 04/2010 - 12/2005
3	Adenosine KinaseIBA 01/2008 - 01/2007
2	Biomarkers (Surrogate Marker)IBA 01/2021 - 01/2021
2	MetalsIBA 01/2021 - 01/2018
2	Transcription Factors (Transcription Factor)IBA 01/2021 - 01/2013
2	AcidsIBA 01/2021 - 01/2007
2	UbiquitinIBA 01/2020 - 04/2016
2	7- nitro- 5- phenyl- 1- (pyrrolidin- 1- ylmethyl)- 1H- benzo(e)(1,4)diazepin- 2(3H)- oneIBA 01/2019 - 01/2013
2	ResveratrolIBA 01/2018 - 01/2013
2	Sirtuin 1IBA 01/2018 - 01/2013
2	entinostat (MS 275)IBA 01/2018 - 01/2013
2	IronIBA 01/2018 - 12/2005
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 09/2015 - 01/2015
2	Dihydrotachysterol (AT 10)IBA 08/2015 - 12/2007
2	RE1-silencing transcription factorIBA 05/2015 - 02/2013
2	NF-kappa B (NF-kB)IBA 01/2013 - 01/2013
2	Protons (Proton)IBA 01/2011 - 02/2008
2	Acid Sensing Ion ChannelsIBA 01/2011 - 02/2008
2	Adenosine (Adenocard)FDA LinkGeneric 01/2008 - 05/2007
1	CalpainIBA 06/2022
1	CytokinesIBA 01/2022
1	Collagenases (Collagenase)FDA Link 01/2021
1	Transcription Factor MTF-1IBA 01/2021
1	salicylhydroxamic acid (SHAM)IBA 01/2021
1	Tissue Plasminogen Activator (Alteplase)FDA Link 01/2021
1	Sodium Channels (Sodium Channel)IBA 01/2021
1	3' Untranslated Regions (3' UTR)IBA 12/2019
1	ORAI1 ProteinIBA 01/2019
1	AMP-Activated Protein KinasesIBA 01/2018
1	Valproic Acid (Depakote)FDA LinkGeneric 01/2018
1	CopperIBA 01/2018
1	ZincIBA 01/2018
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 01/2017
1	Urokinase Plasminogen Activator ReceptorsIBA 01/2017
1	K Cl- CotransportersIBA 10/2016
1	Adenosine Triphosphatases (ATPase)IBA 10/2016
1	Sodium-Hydrogen ExchangersIBA 10/2016
1	UbiquitinsIBA 04/2016
1	Calbindin 2IBA 03/2016
1	Calcium-Binding ProteinsIBA 03/2016
1	Adenosine Triphosphate (ATP)IBA 01/2016
1	Peptides (Polypeptides)IBA 09/2015
1	5- amino- N- butyl- 2- (4- ethoxyphenoxy)- benzamide hydrochlorideIBA 08/2015
1	Hypoxia-Inducible Factor 1IBA 05/2015
1	Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA 01/2015
1	Peptide Hydrolases (Proteases)FDA Link 02/2014

Therapy/Procedure

4	Therapeutics 01/2021 - 01/2009
2	Ischemic Postconditioning 01/2021 - 01/2011
1	Drug Therapy (Chemotherapy) 01/2022
1	Precision Medicine 01/2021
1	Intraventricular Infusions 12/2019
1	Intravenous Administration 01/2019
1	Denervation 12/2018